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KMID : 0811720040080000201
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Korean Journal of Physiology & Pharmacology
2004 Volume.8 No. 0 p.201 ~ p.0
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nfluence of Salt Loading on Cadmium-induced Antinatriuresis in Rats
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Kim Yong-Kyu
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Abstract
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The hypertension induced by cadmium exposure is commonly resulted from the renal salt retention. However, there is some conflicting information that exists regarding the effects of cadmium on electrolyte balance and renin-angiotensin system. Changes in renal electrolyte handling and aldosterone secretion during the loading of different types of sodium salts in cadmium-exposed animals have not been explored. In this study, we attempted to determine whether isotonic bicarbonate and chloride sodium salt loading cause changes in renal electrolytes excretion and renin-angiotensin-aldosterone system in Sprague-Dawley male rats with cadmium adminstration (2 mg Cd/kg/day, s.c. injection for 3 days). Our data showed that the fractional sodium excretion was significantly decreased by cadmium in sodium bicarbonate-treated group as in control cadmium group, but there was no significant change in sodium chloride/cadmium-treated group. The plasma renin activity was diminished by cadmium treatment in both control and salt-loaded groups, but cadmium-induced aldosterone secretion was greatly suppressed by salt-loading. The plasma aldosterone concentration in the cadmium/salt-loaded groups was not significantly different from the normal control group. Even though the antinatriuretic effect of cadmium was blunted under the condition of salt loading, cadmium still prevented the sodium excretion in sodium bicarbonate-treated group, but not in sodim chloride group. Therefore, this study suggests that cadmium indirectly stimulates aldosterone secretion, and that systemic acid-base balance may affect the cadmium-induced antinatriuresis.
Source: Korean Journal of Physiology & Pharmacology.2004 Oct;8(Suppl I):S145-S145
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KEYWORD
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Cadmium, Renal function, Renin-angiotensin system
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